Thiourea → HCID 18801823, compound

HRID 1580638Notes

Reaction equation

HRID 1580638 reaction equation
Br[CH:2]([C:7](=O)[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[CH2:3][C:4]([OH:6])=[O:5].[NH2:16][C:17]([NH2:19])=[S:18]>C(O)(C)C>[NH2:19][C:17]1[S:18][C:2]([CH2:3][C:4]([OH:6])=[O:5])=[C:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:16]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 38961393-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID

Product 1

HCID 18801823HCID 18801823, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 10 grams of β-bromo-β-p-fluorobenzoyl-propionic acid and 2.77 grams of thio-urea in 60 c.c. of isopropyl alcohol is refluxed for 1 hour. After cooling, the precipitated solid is filtered off and recrystallised from isopropyl alcohol, m.p. 267°-268°C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid is filtered off
  3. customrecrystallised from isopropyl alcohol, m.p. 267°-268°C.

Sources & evidence

ORD record
ord-964fe9f9031344d6b3ec406a8ef840dc
Source dataset
uspto-grants-1976_01
Patent number
US03933838

Reaction notes

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