2-pentynylamine → HCID 178446264, compound

HRID 1580647Notes

Reaction equation

HRID 1580647 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1.[CH2:23]([NH2:28])[C:24]#[C:25][CH2:26][CH3:27]>O1CCCC1>[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:28][CH2:23][C:24]#[C:25][CH2:26][CH3:27])[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1

Participants

4

Reactant 2

HCID 112057172-pentynylamineHCID 12947027HCID 12947027, compound

Product 1

HCID 178446264HCID 178446264, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 10.0 g. of 1,3-dihydro-7-(trifluoromethyl)-5-phenyl-2H-1,4-benzodiazepine-2-thione (V), 10.0 g. of 2-pentynylamine, and 150 ml. of dry tetrahydrofuran is stirred under nitrogen at ambient temperature for about 5 hours and then concentrated in vacuo. The residue thus obtained is recrystallized from methanol to give 7-trifluoromethyl-5-phenyl-2-(2-pentynylamino)-3H-1,4-benzodiazepine.

Workup

  1. additionA mixture of 10.0 g
  2. concentrationconcentrated in vacuo
  3. customThe residue thus obtained
  4. customis recrystallized from methanol

Sources & evidence

ORD record
ord-2f99ab839b7c43c7b41529024b4d3746
Source dataset
uspto-grants-1976_01
Patent number
US03933794

Reaction notes

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