N-Acetylsulfanilyl chloride → N-{4-[(1-Butylpiperidin-4-yl)sulfamoyl]phenyl}acetamide

Participants

Reaction Steps

7.0 Grams of N-acetylsulphanilyl chloride were added in portions to a stirred, ice cooled, mixture of 4.7 grams of 4-amino-1-n-butyl piperidine and 6.3 grams of sodium bicarbonate in 75 milliliters of water and 35 milliliters of chloroform. After stirring overnight at room temperature the mixture was filtered, washed with water, and dried to give 4.2 grams of the title compound. Melting Point 174°-175°C.

Provenance & Evidence