Tris(hydroxymethyl)aminomethane → HCID 178439278, compound

HRID 1580701Notes

Reaction equation

HRID 1580701 reaction equation
[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]3[NH:18][N:17]=[N:16][N:15]=3)=[CH:10][C:9](=[O:19])[C:8]=2[C:7]([O:20][CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[OH:26][CH2:27][C:28]([CH2:32][OH:33])([CH2:30][OH:31])[NH2:29]>C(O)C.CCOCC>[OH2:12].[OH:26][CH2:27][C:28]([CH2:32][OH:33])([CH2:30][OH:31])[NH2:29].[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]3[NH:15][N:16]=[N:17][N:18]=3)=[CH:10][C:9](=[O:19])[C:8]=2[C:7]([O:20][CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]3[NH:15][N:16]=[N:17][N:18]=3)=[CH:10][C:9](=[O:19])[C:8]=2[C:7]([O:20][CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[OH:20][CH2:7][C:8]([NH2:29])([CH2:9][OH:19])[CH2:13][OH:12]

Participants

5

Reactant 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 178439275HCID 178439275, compound

Product 1

HCID 178439278HCID 178439278, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

5 Parts of 5-[8-allyl-5-(3-methylbutoxy)-4-oxo-4H-1-benzopyran-2-yl]tetrazole and 1.76 parts of tris-(hydroxymethyl)methylamine were dissolved in ethanol with heating. The resulting solution was cooled, diluted with ether and the resulting crystalline solid was collected, washed with ether and dried in vacuo to give 5.6 parts of 5-[8-allyl-5-(3-methylbutoxy)-4-oxo-4H-1-benzopyran-2-yl]tetrazole tris-(hydroxymethyl)methylamine salt hemihydrate.

Workup

  1. temperaturewith heating
  2. temperatureThe resulting solution was cooled
  3. customthe resulting crystalline solid was collected
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-1039d85d083c4eccba2c64bef57f705c
Source dataset
uspto-grants-1976_01
Patent number
US03933844

Reaction notes

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