1-Methylpiperazine → HCID 21518337, compound

HRID 1580817Notes

Reaction equation

[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([CH:13]([CH3:17])[C:14](Cl)=[O:15])=[CH:12][C:7]=2[CH2:6][CH2:5][C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([CH:13]([CH3:17])[C:14]([N:26]3[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]3)=[O:15])=[CH:12][C:7]=2[CH2:6][CH2:5][C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 21518331HCID 21518331, compound

Product 1

HCID 21518337HCID 21518337, compoundYield 103%

Procedure

Following the procedure of Example 6 but starting with 2-(5oxo-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)propionyl chloride (8 g.) and 1-methylpiperazine (8.2 g.), 4-[2-(5-oxo-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)propionyl]-1-methylpiperazine (10 g.) is obtained in the form of an oil.

Sources & evidence

ORD record: ord-b2c36f11e05b4ac78aef4d3852e3a21d
Source dataset: uspto-grants-1976_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03933905

Reaction notes

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