Sodium Hydroxide → HCID 86732999, compound

HRID 1580833Notes

Reaction equation

HRID 1580833 reaction equation
C(NC1C=CC([NH:11][C:12]2[C:20]([S:21](=[O:34])(=[O:33])[NH:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29]C(=O)C)=[CH:25][CH:24]=3)=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:35][CH2:36][CH:37]=[CH:38][CH3:39])=CC=1)(=O)C.[OH-].[Na+]>>[NH2:11][C:12]1[C:20]([S:21](=[O:34])(=[O:33])[NH:22][C:23]2[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=2)=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[C:14]([NH:11][C:12]2[CH:20]=[CH:19][CH:15]=[CH:14][CH:13]=2)[C:13]=1[NH:35][CH2:36][CH:37]=[CH:38][CH3:39]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54191869HCID 54191869, compound

Product 1

HCID 86732999HCID 86732999, compound

Procedure

The mixture of 1.3 g of 4-(4-acetamidophenylamino)-3-but-2-enylamino-5-(4-acetamidophenylsulfamoyl)-benzoic acid and 13 ml of 2 N aqueous sodium hydroxide is refluxed for 1 hour under nitrogen. After cooling to room temperature it is filtered, the filtrate acidified with glacial acetic acid to a pH of 4-5 and the precipitate formed filtered off and washed with water, to yield the 4-(4-aminophenylamino-3-but-2-enylamino-5-(4-aminophenylsulfamoyl)-benzoic acid melting at about 130°.

Workup

  1. temperatureis refluxed for 1 hour under nitrogen
  2. filtrationis filtered
  3. customthe precipitate formed
  4. filtrationfiltered off
  5. washwashed with water

Sources & evidence

ORD record
ord-e222affdbb254022a251dcec73c26d27
Source dataset
uspto-grants-1976_01
Patent number
US03933906

Reaction notes

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