Sodium Hydroxide → HCID 86732999, compound

Participants

Reaction Steps

The mixture of 1.3 g of 4-(4-acetamidophenylamino)-3-but-2-enylamino-5-(4-acetamidophenylsulfamoyl)-benzoic acid and 13 ml of 2 N aqueous sodium hydroxide is refluxed for 1 hour under nitrogen. After cooling to room temperature it is filtered, the filtrate acidified with glacial acetic acid to a pH of 4-5 and the precipitate formed filtered off and washed with water, to yield the 4-(4-aminophenylamino-3-but-2-enylamino-5-(4-aminophenylsulfamoyl)-benzoic acid melting at about 130°.

Provenance & Evidence