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HRID1580862

反应详情

EQUATION

反应方程式

HRID 1580862 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：COC(=O)[C@@H](N)CC(C)C
HCID65105

(S)-2-Amino-4-methylpentanoic acid methyl ester

C7H15NO2

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1
HCID7021351

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1
HCID12814329

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

16.7 g of H-Leu-OMe and 46.0 g of Z-Asn-ONP are dissolved in 100 ml of freshly distilled dimethylformamide. The solution is allowed to stand for 19 hours at 25°C. Thereafter 1.2 liters of water are added and the crystalline precipitate is filtered off. The dipeptide derivative is dried at 40°C in vacuo and is then twice recrystallised from methanol-water. Melting point 180°-181°C; [α]20D = + 9° (c = 2.05 in chloroform).

WORKUP

后处理

  1. filtrationthe crystalline precipitate is filtered off
  2. dry with materialThe dipeptide derivative is dried at 40°C in vacuo
  3. customis then twice recrystallised from methanol-water
  4. custom[α]20D = + 9° (c = 2.05 in chloroform)