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HRID1580887

反应详情

EQUATION

反应方程式

HRID 1580887 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1
HCID111333

N2-Benzyl p-nitrophenyl N2-carboxy-L-(2-aminoglutaramate)

C19H19N3O7

结构：CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)OC(C)(C)C)C(=O)NCC(=O)OC
HCID131709987

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OCc1ccccc1)[C@@H](C)OC(C)(C)C)C(=O)NCC(=O)OC
HCID131709986

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

4.6 g of the H-Thr(tBu)-Ala-Ile-Gly-OMe described under 28), in 30 ml of dimethylformamide, are mixed with 3.5 g of Z-Gln-ONP and stirred at room temperature until the mixture becomes solid. After allowing to stand overnight the mixture is diluted with ether and the precipitate is filtered off and washed with ether until free of nitrophenol. The protected pentapeptide shows Rf =0.14 in the system chloroform-methanol (95.5 ) in a thin layer chromatogram on silica gel. Melting point: >250°C.

WORKUP

后处理

  1. filtrationthe precipitate is filtered off
  2. washwashed with ether until free of nitrophenol