Hydrochloric Acid → H-Gln-Asn-Phe-OCH3 hydrochloride

HRID 1580890Notes

Reaction equation

HRID 1580890 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:27]([O:29][CH3:30])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH2:12][C:13](=[O:15])[NH2:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[ClH:41]>CO.O1CCOCC1.[C].[Pd]>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:27]([O:29][CH3:30])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH2:12][C:13](=[O:15])[NH2:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[ClH:41]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 131709988Z-Gln-Asn-Phe-OCH3

Product 1

HCID 131709989H-Gln-Asn-Phe-OCH3 hydrochloride

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 312751,4-DioxaneSolventHCID 178418390HCID 178418390, compoundSolvent

Procedure

14.1 g of Z-Gln-Asn-Phe-OCH3 are hydrogenated at 45°C in 800 ml of methanol with the addition of 8.5 ml of 3N-hydrogen chloride in dioxan and 2.4 g of 10% palladium carbon. When the hydrogen uptake ceases, the batch is filtered and evaporated. The residue is processed without purification.

Workup

  1. filtrationWhen the hydrogen uptake ceases, the batch is filtered
  2. customevaporated
  3. customThe residue is processed without purification

Sources & evidence

ORD record
ord-2973012baa8a4fb3beca0a375bc097d3
Source dataset
uspto-grants-1976_01
Patent number
US03934008

Reaction notes

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