反应详情

温度

-30 °C

A solution of 54.0g of 2-amino-3-methylpyridine, 144.0g of methyl butyrylacetate, 5.0g of p-toluenesulfonic acid, and 750ml of ethylene glycol monomethyl ether is heated in a nitrogen atmosphere, under reflux, for 60 hours. The solution is concentrated to dryness in vacuo, and the residual oil extracted with two 250ml portions of pentane. The pentane solution is concentrated to a volume of 250ml and cooled at -30°C to yield the title compound, melting point 59°-60°C.

1. temperatureunder reflux, for 60 hours
2. concentrationThe solution is concentrated to dryness in vacuo
3. extractionthe residual oil extracted with two 250ml portions of pentane
4. concentrationThe pentane solution is concentrated to a volume of 250ml