Ethanol → Prazosin

Participants

Reaction Steps

To a stirred solution of 1.78 g. (0.01 mole) of 4,5-dimethoxy-2-aminobenzonitrile in 50 ml. of anhydrous ethanol is added 10 ml. of triethylamine, followed by 2.88 g. (0.01 mole) of ethyl 4-(2-furoyl)piperazin-1-ylformimidate hydrochloride. The reaction mixture is stirred at ambient temperature for 5 hours, and then it is heated under reflux for 12 hours. At this point, all the solvents are removed by evaporation in vacuo, and the residue is triturated under water. The solid is filtered off and dried, yielding crude 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline.

Provenance & Evidence