反应详情

To a stirred solution of 1.78 g. (0.01 mole) of 4,5-dimethoxy-2-aminobenzonitrile in 50 ml. of anhydrous ethanol is added 10 ml. of triethylamine, followed by 2.88 g. (0.01 mole) of ethyl 4-(2-furoyl)piperazin-1-ylformimidate hydrochloride. The reaction mixture is stirred at ambient temperature for 5 hours, and then it is heated under reflux for 12 hours. At this point, all the solvents are removed by evaporation in vacuo, and the residue is triturated under water. The solid is filtered off and dried, yielding crude 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline.

1. temperatureit is heated
2. temperatureunder reflux for 12 hours
3. customAt this point, all the solvents are removed by evaporation in vacuo
4. customthe residue is triturated under water
5. filtrationThe solid is filtered off
6. customdried