Ethanol → HCID 21560784, compound

Participants

Reaction Steps

A solution containing 2.62 g. (0.01 mole) of 3,4,5-trimethoxy-2-aminobenzamidine hydrochloride and 1.83 g. (0.01 mole) of 1-cyano-4-ethoxycarbonylpiperazine in 50 ml. of anhydrous ethanol is stirred at ambient temperature overnight. A 5-ml. aliquot of triethylamine is then added and the reaction mixture is heated under reflux for 12 hours. It is then worked up as described in Example XI, giving 6,7,8-trimethoxy-4-amino-2-[4-ethoxycarbonylpiperazin-1-yl]quinazoline.

Provenance & Evidence