Ethanol → HCID 21560784, compound

HRID 1580971Notes

Reaction equation

HRID 1580971 reaction equation
Cl.[CH3:2][O:3][C:4]1[C:5]([NH2:17])=[C:6]([CH:10]=[C:11]([O:15][CH3:16])[C:12]=1[O:13][CH3:14])[C:7]([NH2:9])=[NH:8].[C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:22][CH2:21]1)#N.C(O)C>C(N(CC)CC)C>[CH3:16][O:15][C:11]1[CH:10]=[C:6]2[C:5](=[C:4]([O:3][CH3:2])[C:12]=1[O:13][CH3:14])[N:17]=[C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:22][CH2:21]1)[N:8]=[C:7]2[NH2:9]

Participants

5

Reactant 3

HCID 702EthanolHCID 14023627Ethyl 4-cyanopiperazine-1-carboxylateHCID 21560802HCID 21560802, compound

Product 1

HCID 21560784HCID 21560784, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A solution containing 2.62 g. (0.01 mole) of 3,4,5-trimethoxy-2-aminobenzamidine hydrochloride and 1.83 g. (0.01 mole) of 1-cyano-4-ethoxycarbonylpiperazine in 50 ml. of anhydrous ethanol is stirred at ambient temperature overnight. A 5-ml. aliquot of triethylamine is then added and the reaction mixture is heated under reflux for 12 hours. It is then worked up as described in Example XI, giving 6,7,8-trimethoxy-4-amino-2-[4-ethoxycarbonylpiperazin-1-yl]quinazoline.

Workup

  1. additionA solution containing 2.62 g
  2. temperaturethe reaction mixture is heated
  3. temperatureunder reflux for 12 hours

Sources & evidence

ORD record
ord-8318332a755a40218e57f4a578472c46
Source dataset
uspto-grants-1976_01
Patent number
US03935213

Reaction notes

Loading…