反应详情

10 g of 5-(3,4-dibromobutyl)picolinic acid was dissolved in 200 ml of ethanol saturated with dry hydrochloride gas and resulting solution was refluxed for six hours. Reaction mixture was evaporated in reduced pressure and resulting pale yellow oil was dissolved in 300 ml of ethanol saturated with dry ammonia gas. The solution was kept to stand at room temperature for three days, and then evaporated in reduced pressure. Resulting solid was crystallized from benzene to give 6.5 g of the pure product as platelets.

1. customresulting solution
2. temperaturewas refluxed for six hours
3. customReaction mixture
4. customwas evaporated in reduced pressure
5. customresulting pale yellow oil
6. customevaporated in reduced pressure
7. customResulting solid
8. customwas crystallized from benzene