Hydrochloric Acid → HCID 21561014, compound

HRID 1580982Notes

Reaction equation

HRID 1580982 reaction equation
C1(O)[C:13]2[C:12]3[C:8](=[CH:9][NH:10][CH:11]=3)[CH:7]=[CH:6][C:5]=2NCN1.[ClH:15].[CH2:16]([OH:18])[CH3:17]>>[ClH:15].[Cl:15][C:5]1[CH:6]=[CH:7][C:17]([C:16]2([OH:18])[C:13]3[C:12](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:11]3=[N:10][CH2:9][CH2:8][CH2:9][N:10]23)=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68134762HCID 68134762, compound

Product 1

HCID 21561014HCID 21561014, compound

Procedure

The above prepared tetrahydropyrimidoisoindolol is dissolved in ethanol and admixed with an aqueous solution containing an equivalent amount of hydrochloric acid. The mixture is stirred for ten minutes and the solvent removed by evaporation. In this manner, is obtained 6-(4-chlorophenyl)-2,3,4,6-tetrahydropyrimido[2,1-a]isoindol-6-ol hydrochloride, m.p. 232°-4°C., as a white crystalline solid, which is soluble in hot water.

Workup

  1. customthe solvent removed by evaporation

Sources & evidence

ORD record
ord-ff7185b4dfa34ee1a1a9b66d53524597
Source dataset
uspto-grants-1976_01
Patent number
US03935218

Reaction notes

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