Hydrochloric Acid → HCID 21560860, compound

HRID 1580987Notes

Reaction equation

HRID 1580987 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:20])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]3=[N:17][CH2:18][CH2:19][N:9]23)=[CH:4][CH:3]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:10]2[NH:17][CH2:18][CH2:19][N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 4020Mazindol

Product 1

HCID 21560860HCID 21560860, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ten grams of 5-(4-chlorophenyl)-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol, as described in Example X, are suspended in 75 ml. of absolute ethanol and then saturated with a continuous flow of hydrochloric acid gas. The resulting solution is filtered, evaporated to dryness and the residue recrystallized from ethanol-ethyl acetate to afford 4'-chloro-2-(2-imidazolin-2-yl)benzophenone hydrochloride, m.p. 170°-2°C., dec., as a white crystalline solid which is soluble in water.

Workup

  1. filtrationThe resulting solution is filtered
  2. customevaporated to dryness
  3. customthe residue recrystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-939ae87b61514b5b914db02d7b7c50cf
Source dataset
uspto-grants-1976_01
Patent number
US03935218

Reaction notes

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