2-(5-Bromopentyl)benzo[de]isoquinoline-1,3-dione → HCID 131710014, compound

HRID 1581023Notes

Reaction equation

HRID 1581023 reaction equation
[ClH:1].C1(C2CCN(C[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]3[C:29](=[O:30])[C:28]4[CH:31]=[CH:32][CH:33]=[C:26]5[C:27]=4[C:22](=[CH:23][CH:24]=[CH:25]5)[C:21]3=[O:34])CC=2)C=CC=CC=1.BrCCCCC[N:41]1[C:50](=O)[C:49]2[CH:52]=[CH:53][CH:54]=[C:47]3[C:48]=2[C:43](=C[CH:45]=[CH:46]3)[C:42]1=O.BrCCCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[ClH:1].[C:47]1([C:48]2[CH2:49][CH2:50][N:41]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]3[C:21](=[O:34])[C:22]4[CH:23]=[CH:24][CH:25]=[C:26]5[C:27]=4[C:28](=[CH:31][CH:32]=[CH:33]5)[C:29]3=[O:30])[CH2:42][CH:43]=2)[CH:46]=[CH:45][CH:52]=[CH:53][CH:54]=1

Participants

4

Reactant 3

HCID 166387912-(5-Bromopentyl)benzo[de]isoquinoline-1,3-dioneHCID 203645072-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dioneHCID 131710013HCID 131710013, compound

Product 1

HCID 131710014HCID 131710014, compound

Procedure

Following the procedure of part (b) of Example 56 but substituting 2-(5-bromopentyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione, one obtains 2-[5-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)pentyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride (1:1). The product is purified by recrystallization from n-butanol; m.p. 207°-210°.

Sources & evidence

ORD record
ord-844d3e18ddae47679135d1c3e2069ff5
Source dataset
uspto-grants-1976_01
Patent number
US03935227

Reaction notes

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