Hydrochloric Acid → 35697-20-2

HRID 1581078Notes

Reaction equation

HRID 1581078 reaction equation
[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][CH:9]([OH:15])[CH2:10]2.[CH2:21]=O.[ClH:23]>C(O)C>[ClH:23].[CH:18]([N:17]1[CH2:16][CH:2]([CH2:3][O:4][C:5]2[C:6]3[CH2:7][CH2:8][CH:9]([OH:15])[CH2:10][C:11]=3[CH:12]=[CH:13][CH:14]=2)[O:1][CH2:21]1)([CH3:20])[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 12445651HCID 12445651, compound

Product 1

HCID 7060178135697-20-2

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 5.58 g. (0.02 mole) of 1,2,3,4-tetrahydro-5-[2-hydroxy-3-(isopropylamino)propoxy]-2-naphthol in 30 ml. of 99% ethanol is treated with 4 ml. of 33% formalin and heated under reflux for 12-16 hours. The solution is acidified with hydrochloric acid in ethanol and the oxazolidine hydrochloride precipitated by the addition of ether.

Workup

  1. temperatureunder reflux for 12-16 hours
  2. customthe oxazolidine hydrochloride precipitated by the addition of ether

Sources & evidence

ORD record
ord-9d1ecf27e3f440f3b648e884d175d8a0
Source dataset
uspto-grants-1976_01
Patent number
US03935267

Reaction notes

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