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0 °C

A mixture of 3-hydroxy-2-(7-hydroxyheptyl)-cyclopentanecarbaldehyde (6 g.) [prepared as described in Example 1]and 2-ethylhexanoylmethylenetriphenylphosphorane (9g.) in dry tetrahydrofuran (70 ml.) was heated under refux under nitrogen for 6 hours. The solvent was removed in vacuo and the residue was triturated with petrol (b.p. 40°-α°C.) with cooling to 0°C. and filtered to remove triphenylphosphine oxide. Evaporation of the filtrate then gave crude 2-(7-hydroxyheptyl)-3-(4-ethyl-3-oxo-1-octenyl)cyclopentanol (4.4 g.), ν max 1620 cm-1, 1655 cm-1 (liquid film), which was used in the next step without further purification.

1. customprepared
2. temperaturewas heated under refux under nitrogen for 6 hours
3. customThe solvent was removed in vacuo
4. customthe residue was triturated with petrol (b.p. 40°-α°C.)
5. filtrationfiltered
6. customto remove triphenylphosphine oxide
7. customEvaporation of the filtrate