(R)-1-(4-hydroxyphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester → HCID 178501349, compound

HRID 1581274Notes

Reaction equation

HRID 1581274 reaction equation
CC(Cl)c1cccnc1.COC(=O)[C@@H]1CC(=O)N(c2ccc(O)cc2)C1>CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>COC(=O)[C@@H]1CC(=O)N(c2ccc(OC(C)c3cccnc3)cc2)C1

Participants

6

Reactant 2

HCID 785702(R)-1-(4-hydroxyphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl esterHCID 149329503-(1-Chloroethyl)pyridine

Product 1

HCID 178501349HCID 178501349, compound

Reagents, catalysts & solvents 3

HCID 4875Potassium IodideReagentHCID 10796Cesium carbonateReagentHCID 6228DimethylformamideSolvent3×

Conditions

Temperature
70 °C

Workup

  1. aliquotNo procedure recorded
  2. additionDilution of the aliquot (2 uL) with DMSO (200 uL).

Sources & evidence

ORD record
ord-cf1bb305cae84119a2561265ddac8c7c
Source dataset
Fig 7 data from Golden paper
Original link
View source

Reaction notes

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