Hydrochloric Acid → HCID 9943365, compound

HRID 1581488Notes

Reaction equation

HRID 1581488 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[N:12]=[N:13][C:14]([O:17]C)=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][N:12]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11637775HCID 11637775, compound

Product 1

HCID 9943365HCID 9943365, compoundYield 43.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-(3-chloro-benzenesulfonyl)-6-methoxy-pyridazine (148 mg), dioxane (2 mL) and concentrated hydrochloric acid (0.5 mL) was prepared and refluxed for 30 minutes. The reaction mixture was then evaporated to dryness and the residue was extracted with ethyl acetate (2×10 mL). The ethyl acetate mixture was collected, dried over anhydrous sodium sulfate, filtered and the filtrate was evaporated to dryness to afford 6-(3-chloro-benzenesulfonyl)-2H-pyridazin-3-one as white solid (38%, 61 mg); mp, 222-223° C.: NMR, 7.11 (d, 1H), 7.74 (t, 1H), 7.86-8.04 (m, 4H), 13.86 (s, 1H).

Workup

  1. customwas prepared
  2. temperaturerefluxed for 30 minutes
  3. customThe reaction mixture was then evaporated to dryness
  4. extractionthe residue was extracted with ethyl acetate (2×10 mL)
  5. customThe ethyl acetate mixture was collected
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-addcd77b2d604050add606c7b2f3c844
Source dataset
uspto-grants-2004_05
Patent number
US06730674B2

Reaction notes

Loading…