反应详情

A mixture of 6-methoxy-pyridazine-3-thiol (7.1 g), methanol (100 mL), water (100 mL), and potassium hydrogen fluoride (39 g) was prepared and stirred at-10° C. for 30 minutes. Chlorine gas was bubbled into the mixture at a rate to ensure that the temperature did not exceed −10° C. The whitish-yellow reaction mixture was then poured into ice-cold water (50 mL) and the resulting white solid was filtered and air dried to afford the title compound (74%, 7.1 g); mp, 87-88° C.

1. customwas prepared
2. customChlorine gas was bubbled into the mixture at a rate
3. customdid not exceed −10° C
4. additionThe whitish-yellow reaction mixture was then poured into ice-cold water (50 mL)
5. filtrationthe resulting white solid was filtered
6. customair dried