化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 3-Fluorosulfonyl-6-methoxypyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | HCID 5281010 | HCID 5281010 | — |
| 反応物 | Potassium fluoride, 99%, spray-dried | HCID 53443437 | — |
| 反応物 | HCID 178492798 | HCID 178492798 | — |
| 生成物 | 3-Fluorosulfonyl-6-methoxypyridazine | HCID 11030636 | 74% |
反応手順
A mixture of 6-methoxy-pyridazine-3-thiol (7.1 g), methanol (100 mL), water (100 mL), and potassium hydrogen fluoride (39 g) was prepared and stirred at-10° C. for 30 minutes. Chlorine gas was bubbled into the mixture at a rate to ensure that the temperature did not exceed −10° C. The whitish-yellow reaction mixture was then poured into ice-cold water (50 mL) and the resulting white solid was filtered and air dried to afford the title compound (74%, 7.1 g); mp, 87-88° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06730674B2 |
| 出典データセット | uspto-grants-2004_05 |
| ORD ID | ord-9610e88b339c480b8105dd47a552b398 |
| 出典メモ | uspto-grants-2004_05 |