Diethyl (ethoxymethylene)malonate → HCID 22722029, compound

HRID 1581558Notes

Reaction equation

HRID 1581558 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][N:3]=1.C(O[CH:12]=[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])C>>[Br:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 122159945-Amino-2-bromopyrimidine

Product 1

HCID 22722029HCID 22722029, compound

Conditions

Temperature
135 °C

Procedure

A mixture of 2-bromopyrimidin-5-amine (Krchnak, V.; Arnold, Z. Coll. Czech. Chem. Commun. 1975, 40, 1396-1402) (3.48 g) and diethyl ethoxymethylenemalonate (5.05 mL) is heated to 135° C. for 1 h. The mixture is allowed to cool affording a solid.

Workup

  1. temperatureto cool
  2. customaffording a solid

Sources & evidence

ORD record
ord-a2fd537d6fbf411aa0f5a4d71d8614a9
Source dataset
uspto-grants-2004_05
Patent number
US06730682B2

Reaction notes

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