Hydrochloric Acid → HCID 72644366, compound

HRID 1581645Notes

Reaction equation

HRID 1581645 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH2:15][C:16]([O:18]CC)=[O:17])[CH:14]=2)[S:3]1.Cl>C(O)(=O)C>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=2)[S:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 72644365HCID 72644365, compound

Product 1

HCID 72644366HCID 72644366, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 2-[5-[(2,4-dioxothiazolidin-5-ylidene)methyl]-2-methoxyphenyl]acetate (1.29 g, 4.01 mmol), concentrated hydrochloric acid (20 mL)and acetic acid (20 mL) were mixed and refluxed for 2.5 hours. After allowed to stand for cooling, ice water was added thereto and the precipitated crystals were collected by filtration, washed with water, and then dried to obtain 1.13 g (96%) of title compound as yellow powder.

Workup

  1. temperaturerefluxed for 2.5 hours
  2. temperaturefor cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-9485b8579f564bd6bc7d9e08616292cc
Source dataset
uspto-grants-2004_05
Patent number
US06730687B1

Reaction notes

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