反应详情

5-[(4-Methoxyphenyl)methylidene]thiazolidine-2,4-dione (6.00 g, 25.5 mmol), 10% palladium on carbon (6.00 g) and a mixed solvent of tetrahydrofuran and ethanol (2:1 v/v, 300 mL) were mixed, and hydrogenation was performed at room temperature and at an initial pressure of 294 kPa. After completion of the reaction, catalyst was filtered and the filtrate was concentrated. The residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v) to obtain 5.84 g (97%) of the title compound as colorless powder.

1. customwas performed at room temperature
2. customAfter completion of the reaction, catalyst
3. filtrationwas filtered
4. concentrationthe filtrate was concentrated
5. customThe residue was purified by silica gel chromatography (eluate n-hexane: ethyl acetate=2:1 v/v)