Acetic Acid → Ibuprofen, (+-)-

HRID 1581691Notes

Reaction equation

HRID 1581691 reaction equation
[CH:1](Cl)(Cl)Cl.[CH3:5][OH:6].[OH2:7].CO[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1.[CH2:18](O)[CH3:19].S(=O)(=O)(O)O.[C:26](O)(=O)[CH3:27]>>[OH:6][C:5]([CH:26]([C:10]1[CH:17]=[CH:16][C:13]([CH2:14][CH:18]([CH3:19])[CH3:1])=[CH:12][CH:11]=1)[CH3:27])=[O:7]

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 1118Sulfuric AcidHCID 312444-MethoxybenzaldehydeHCID 21866399Chloroform methanol water

Product 1

HCID 3672Ibuprofen, (+-)-

Procedure

The synthesized compounds were subjected to TLC analysis under the following conditions: Silica gel 60 on aluminum sheet. Eluent is chloroform:methanol:water (65:35:5, v/v). Indicator is a spray of the composition: 4-methoxybenzaldehyde (10 ml), absolute ethanol (200 ml), 98% sulfuric acid (10 ml) and glacial acetic acid (2 ml). The chromatogram is sprayed with the indicator and then charred at 100° C.

Workup

  1. customcharred at 100° C.

Sources & evidence

ORD record
ord-e5b95a60a78e44618a8af4e776eca693
Source dataset
uspto-grants-2004_05
Patent number
US06730696B1

Reaction notes

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