HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[2-(5-nitro-1H-indol-3-yl)ethyl]acetamide → N-[2-(5-Amino-1H-indol-3-yl)ethyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[2-(5-nitro-1H-indol-3-yl)ethyl]acetamide | HCID 906605 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[2-(5-Amino-1H-indol-3-yl)ethyl]acetamide | HCID 22722278 | — |
Reaction Steps
The product from Example 2 (0.05 mmol) is taken into ethanol (3 mL) and hydrogenated 6 h at 3 atmospheres of H2 pressure over a catalytic amount of 10% Pd/C. The catalyst is removed by filtration through Celite and the solvent removed in vacuo, affording the title compound. This product is somewhat air sensitive and is used immediately for subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06730707B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-3d06ed28c8df4b51a5d3ea72070d9562 |
| Source note | uspto-grants-2004_05 |