4'-Hydroxyacetophenone → HCID 66935305, compound

HRID 1581790Notes

Reaction equation

HRID 1581790 reaction equation
CC(C1C=CC(O)=CC=1)=O.CN(C)C=CC(C1C=CC=C(O)C=1)=O.[CH3:25][N:26]([CH3:38])[CH:27]=[CH:28][C:29]([C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1)=[O:30].O1C(C2C=C(O)C=CC=2)=CC=N1>>[CH3:38][N:26]([CH3:25])[CH:27]=[CH:28][C:29]([C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1)=[O:30].[O:30]1[C:29]([C:31]2[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=2)=[CH:28][CH:27]=[N:26]1

Participants

6

Reactant 4

HCID 74694'-HydroxyacetophenoneHCID 227234713-(1,2-Oxazol-5-yl)phenolHCID 66935305HCID 66935305, compoundHCID 69517765HCID 69517765, compound

Product 2

HCID 66935305HCID 66935305, compoundHCID 135744209Phenol, 4-(5-isoxazolyl)- (9CI)

Procedure

3-(Dimethylamino)-1-(4-hydroxyphenyl)-2-propen-1-one is prepared from 4-hydroxyacetophenone substantially in the same manner as that described for 3-(dimethylamino)-1-(3-hydroxyphenyl)-2-propen-1-one (Epoxide 24). 4-(5-Isoxazolyl)phenol is prepared from 3-(dimethylamino)-1-(4-hydroxyphenyl)-2-propen-1-one substantially in the same manner as that described for 3-(5-isoxazolyl)phenol (Epoxide 25). This phenolic product is reacted with (2S)-glycidyl 3-nitrobenzenesulfonate substantially as described for Epoxide 1 to yield the title epoxide.

Sources & evidence

ORD record
ord-6ce122e7c9b343baa0ac764e679d5425
Source dataset
uspto-grants-2004_05
Patent number
US06730792B2

Reaction notes

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