HCID 22723464, compound → HCID 22723455, compound

HRID 1581798Notes

Reaction equation

HRID 1581798 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]=[CH:17][O:18][CH:19]=1)C1C=CC=CC=1>ClCCl.[Pd]>[O:18]1[CH:19]=[C:15]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[OH:8])[N:16]=[CH:17]1

Participants

4

Reactant 1

HCID 22723464HCID 22723464, compound

Product 1

HCID 22723455HCID 22723455, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of the oxazole from above (1.99 g, 7.92 mmol) in dichloromethane (20 ml) is added 10% palladium on carbon (1.99 g). The mixture is put under an atmosphere of hydrogen, stirred at room temperature over night, then filtered through Celite. The solvent is removed under reduced pressure to leave 2-(oxazol-4-yl)phenol (1.15 g, 90%), which is used for the next step without further purification.

Workup

  1. filtrationfiltered through Celite
  2. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-28d2c149803b48fca9e0788fac35463b
Source dataset
uspto-grants-2004_05
Patent number
US06730792B2

Reaction notes

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