Sodium borohydride → HCID 22723510, compound

HRID 1581826Notes

Reaction equation

HRID 1581826 reaction equation
[C:1]([C:3]([CH3:15])([CH3:14])[C:4](=[O:13])[CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])#[N:2].[BH4-].[Na+]>C1COCC1>[C:1]([C:3]([CH3:15])([CH3:14])[CH:4]([OH:13])[CH2:5][C:6]([O:8][C:9]([CH3:11])([CH3:10])[CH3:12])=[O:7])#[N:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 9813154HCID 9813154, compound

Product 1

HCID 22723510HCID 22723510, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a 300 mL four-necked flask were charged dry THF (105 mL) and tert-butyl 4-cyano-4-methyl-3-oxopentanoate (30.07 g, 0.142 mol), and sodium borohydride (3.24 g, 0.0854 mol) was added. The reaction mass was stirred at room temperature for 2 hr and disappearance of the starting material was confirmed by thin-layer chromatography (TLC). After the confirmation, the reaction mixture was used as it was in Example 3.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-d9b8c03e31c74721b7748850f2510954
Source dataset
uspto-grants-2004_05
Patent number
US06730803B2

Reaction notes

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