反应详情

温度

150 °C

2-formylaminothiophene-3-carboxylic acid ethyl ester (3.0 g, 15.3 mmol) was dissolved in formamide (12 ml), to which ammonium formate (3.0 g, 48.2 mmol) was added and the mixture was stirred at 150° C. for 6 hours. The reaction mixture was allowed to stand overnight at room temperature and the crystals that formed were filtered to obtain 4-hydroxythieno[2,3-d]pyrimidine (1.7 q, 11.0 mmol) having the following physical properties:

1. additionwas added
2. waitto stand overnight at room temperature
3. customthe crystals that formed
4. filtrationwere filtered