Formamide → HCID 178435036, compound

HRID 1581981Notes

Reaction equation

HRID 1581981 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[C:7](OCC)=[O:8].[CH:14]([NH2:16])=O>>[OH:8][C:7]1[C:6]2[C:5]([CH3:12])=[C:4]([CH3:13])[S:3][C:2]=2[N:1]=[CH:14][N:16]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoate

Product 1

HCID 178435036HCID 178435036, compound

Procedure

Using ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate (500 mg, 2.5 mmol) and formamide (5 ml), a similar procedure to a) in Example 19 was carried out to obtain 4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidine (380 mg, 2.1 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-78d722231274482c99204a4c0e4a3722
Source dataset
uspto-grants-2004_05
Patent number
US06734180B1

Reaction notes

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