HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 2-(tert-Butoxycarbonylamino)-5-[(E)-2-(4-methylphenyl)ethenyl]indan | HCID 22719634 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride | HCID 22719590 | — |
Reaction Steps
Using 2-(tert-butoxycarbonylamino)-5-[(E)-2-(4-methylphenyl)ethenyl]indan (20 mg, 0.060 mmol) synthesized in Preparation Example 2, 4N hydrochloric acid-dioxane (2.0 ml) and acetic acid (6.0 ml), a similar procedure to Example 24 was carried out to obtain 2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol) having the following physical properties:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06734180B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-d2497058e0664f74a8173ce962937995 |
| Source note | uspto-grants-2004_05 |