反应详情

3,4-Dihydro-1H-β-carboline-2,9-dicarboxylic acid 2-tert-butyl ester 9-(2,2,2-trichloro-ethyl) ester (3.53 g) and trifluoroacetic acid (5 ml) in dichloromethane (30 ml) were stirred at room temperature for 1.5 h. The mixture was partitioned between 6N NaOH solution (70 ml) and dichloromethane (50 ml). The dichloromethane was washed with water (50 ml) and dried (MgSO4) then the solvent removed under reduced pressure to give the title compound (2.25 g, 81%) as a yellow solid.

1. customThe mixture was partitioned between 6N NaOH solution (70 ml) and dichloromethane (50 ml)
2. washThe dichloromethane was washed with water (50 ml)
3. dry with materialdried (MgSO4)
4. customthe solvent removed under reduced pressure