Pyridine → HCID 19177440, compound

HRID 1582076Notes

Reaction equation

HRID 1582076 reaction equation
[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:11][C:12]([CH3:17])=[CH:13][C:14](Cl)=[O:15].N1C=CC=CC=1>C(Cl)Cl>[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][C:14](=[O:15])[CH:13]=[C:12]([CH3:17])[CH3:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 74644-IsopropylanilineHCID 1023943-Methyl-2-butenoyl chloride

Product 1

HCID 19177440HCID 19177440, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 4-isopropylaniline (5.0 g, 37.0 mmol) in 100 ml of anhydrous CH2Cl2 under argon at 0° C. was added 3,3-dimethylacryloyl chloride (4.12 ml, 37.0 mmol). Pyridine (3.0 ml, 40.6 mmol) was added, and the mixture was stirred at 25° C. for 12 hours. The reaction was quenched with water and extracted with ethyl ether. The organic layer was washed with water, and brine, dried over Na2SO4 and were in vacuo to give the title compound as a light brown solid.

Workup

  1. customThe reaction was quenched with water
  2. extractionextracted with ethyl ether
  3. washThe organic layer was washed with water, and brine
  4. dry with materialdried over Na2SO4

Sources & evidence

ORD record
ord-7d8b6fa59a8e4bcab820737676d953a9
Source dataset
uspto-grants-2004_05
Patent number
US06734193B1

Reaction notes

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