反应详情

温度

100 °C

0.9 g (0.002 Mol) 4-(4-methoxy-2-methoxycarbonylamino-benzothiazol-7-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester were dissolved in a mixture of 7 ml dioxane, 14 ml ethylene glycol and 14 ml 2 N NaOH and heated to 100° C. for 15 h. After cooling to room temperature the pH was adjusted to 7 with 1 N HCl. A precipitation formed, which was filtered, washed with water and dried in vacuo to yield 0.65 g (84%) 4-(2-amino-4-methoxy-benzothiazol-7-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester as a light yellow solid; F.p.: 191-196° C.

1. temperatureAfter cooling to room temperature the pH
2. customA precipitation
3. customformed
4. filtrationwhich was filtered
5. washwashed with water
6. customdried in vacuo