反应详情

The title compound was prepared from 2-chloromethyl-N-[7-(tetrahydro-pyran-4-yl)-4-methoxy-benzothiazol-2-yl]-isonicotinamide (prepared from 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine and 4-(2-chloromethyl)-isonicotinic acid chloride as described for 2-chloromethyl-N-(7-cyclohexyl-4-methoxy-benzothiazol-2-yl)-isonicotinamide) and pyrrolidine as described for N-(7-Cyclohexyl-4-methoxy-benzothiazol-2-yl)-2-pyrrolidin-1-ylmethyl-isonicotinamide and obtained as light yellow solid (62% yield), mp 200-202° C. MS: m/e=453 (M+H+).