Pyrrolidine → N-[4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-pyrrolidin-1-ylmethyl-isonicotinamide
반응식
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][N:28]=1)[C:6]([NH:8][C:9]1[S:10][C:11]2[C:17]([CH:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=2[N:13]=1)=[O:7].[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1.C1(C2C3SC(NC(=O)C4C=CN=C(CN5CCCC5)C=4)=NC=3C(OC)=CC=2)CCCCC1>>[CH3:25][O:24][C:14]1[C:12]2[N:13]=[C:9]([NH:8][C:6](=[O:7])[C:5]3[CH:26]=[CH:27][N:28]=[C:3]([CH2:2][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)[CH:4]=3)[S:10][C:11]=2[C:17]([CH:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[CH:16][CH:15]=1참가 물질
4
반응물 3
생성물 1
실험 절차
The title compound was prepared from 2-chloromethyl-N-[7-(tetrahydro-pyran-4-yl)-4-methoxy-benzothiazol-2-yl]-isonicotinamide (prepared from 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine and 4-(2-chloromethyl)-isonicotinic acid chloride as described for 2-chloromethyl-N-(7-cyclohexyl-4-methoxy-benzothiazol-2-yl)-isonicotinamide) and pyrrolidine as described for N-(7-Cyclohexyl-4-methoxy-benzothiazol-2-yl)-2-pyrrolidin-1-ylmethyl-isonicotinamide and obtained as light yellow solid (62% yield), mp 200-202° C. MS: m/e=453 (M+H+).
출처 및 근거
- ORD 기록
- ord-694cca28438f490fb98e74738277cb22
- 출처 데이터셋
- uspto-grants-2004_05
- 특허 번호
- US06734179B2
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