Hydrochloric Acid → HCID 178481164, compound

HRID 1582229Notes

Reaction equation

HRID 1582229 reaction equation
Br.[NH2:2][C:3]([NH:5][C:6]([C:8]1[N:9]([CH3:26])[C:10]2[C:15]([CH:16]=1)=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:13]=[C:12]([CH2:21][P:22](=[O:25])([OH:24])[OH:23])[CH:11]=2)=[O:7])=[NH:4].[OH-].[Na+].Cl>O>[NH2:4][C:3]([NH:5][C:6]([C:8]1[N:9]([CH3:26])[C:10]2[C:15]([CH:16]=1)=[C:14]([C:17]([F:18])([F:19])[F:20])[CH:13]=[C:12]([CH2:21][P:22](=[O:23])([OH:25])[OH:24])[CH:11]=2)=[O:7])=[NH:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178419586HCID 178419586, compound

Product 1

HCID 178481164HCID 178481164, compoundYield 101.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

[2-[[[Amino(imino)methyl]amino]carbonyl]-1-methyl-4-(trifluoromethyl)-1H-indol-6-yl]methylphosphonic acid hydrobromide (1.37 g, 2.87 mmol) was suspended in distilled water (50 ml), followed by adding thereto a 1.0N aqueous sodium hydroxide solution (8.62 ml, 8.62 mmol) to effect dissolution and adjust the pH to about 11, and the insoluble material was removed by filtration. The filtrate was adjusted to pH 5 to 6 with a 1.0N aqueous hydrochloric acid solution (5.75 ml, 5.75 mmol), and the white solid precipitated was collected by filtration. The white solid obtained was washed with water and then dried under reduced pressure to obtain 1.10 g of [2-[[[amino(imino)methyl]-amino]carbonyl]-1-methyl-4-(trifluoromethyl)-1H-indol-6-yl]methyl-phosphonic acid as a white solid.

Workup

  1. additionby adding
  2. dissolutiondissolution
  3. customthe insoluble material was removed by filtration
  4. customthe white solid precipitated
  5. filtrationwas collected by filtration
  6. customThe white solid obtained
  7. washwas washed with water
  8. customdried under reduced pressure

Sources & evidence

ORD record
ord-40f17458abc54e3599c31e58909c9b89
Source dataset
uspto-grants-2004_05
Patent number
US06734205B2

Reaction notes

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