HCID 30327616, compound → HCID 51629929, compound

Participants

Reaction Steps

A mixture of (3S)-3-(4-benzyl-1-piperazinyl)-1-azabicyclo[2.2.2]octane (1.25 g, 4.37 mmol) and 400 mg of Pd(OH)2 (20 wt % on carbon) in MeOH (60 mL) was stirred at room temperature under hydrogen atmosphere (4 atm) for 6 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give a product (850 mg, quant.).

Provenance & Evidence