HCID 30327616, compound → HCID 51629929, compound

HRID 1582390Notes

Reaction equation

HRID 1582390 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C@H:14]2[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:11]1([C@H:14]2[CH:19]3[CH2:18][CH2:17][N:16]([CH2:21][CH2:20]3)[CH2:15]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 30327616HCID 30327616, compound

Product 1

HCID 51629929HCID 51629929, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A mixture of (3S)-3-(4-benzyl-1-piperazinyl)-1-azabicyclo[2.2.2]octane (1.25 g, 4.37 mmol) and 400 mg of Pd(OH)2 (20 wt % on carbon) in MeOH (60 mL) was stirred at room temperature under hydrogen atmosphere (4 atm) for 6 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give a product (850 mg, quant.).

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customto give a product (850 mg, quant.)

Sources & evidence

ORD record
ord-e557052eb1a94688b83f5466c62a8aee
Source dataset
uspto-grants-2004_05
Patent number
US06734306B2

Reaction notes

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