Acetic Acid → HCID 135476517, compound

HRID 1582433Notes

Reaction equation

HRID 1582433 reaction equation
C([O:9][CH2:10][C@:11]12[C@@H:17]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C@@H:14]([O:15][CH2:16]1)[C@H:13]([N:26]1[CH:34]=[N:33][C:32]3[C:31](=[O:35])[NH:30][CH:29]=[N:28][C:27]1=3)[O:12]2)(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)(=O)C>CO>[CH2:19]([O:18][C@H:17]1[C@H:14]2[O:15][CH2:16][C@:11]1([CH2:10][OH:9])[O:12][C@H:13]2[N:26]1[CH:34]=[N:33][C:32]2[C:31](=[O:35])[NH:30][CH:29]=[N:28][C:27]1=2)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 137178931HCID 137178931, compound

Product 1

HCID 135476517HCID 135476517, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of compound 22 in methanol (20 mL) was added 2M NaOH (2 mL) and 15 min later acetic acid (2 mL). The mixture was cooled in ice-bath, the precipitate was filtered off, washed with water and dried in vacuo. Yield: 0.69 g (85%) of compound 23 as a white solid material.

Workup

  1. temperatureThe mixture was cooled in ice-bath
  2. filtrationthe precipitate was filtered off
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-c80635c0bd0a40d08d491b72c0e2d304
Source dataset
uspto-grants-2004_05
Patent number
US06734291B2

Reaction notes

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