HCID 22720968, compound → HCID 22721068, compound

HRID 1582473Notes

Reaction equation

HRID 1582473 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]3)=[O:21])[C:10]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][C:32]=3[O:39][CH:40]([CH3:42])[CH3:41])=[N:9]2)=[CH:4][CH:3]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]3)=[O:21])[C:10]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][C:32]=3[O:39][CH:40]([CH3:42])[CH3:41])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 22720968HCID 22720968, compound

Product 1

HCID 22721068HCID 22721068, compoundYield 193.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone (2.20 g, 3.60 mmol) was dissolved in dilute hydrochloric acid (0.23 N, 20 mL). The light yellow solution was filtered and lyophilized to give [4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone hydrochloride as a off-white powder (2.26 g, 97%). HR-MS (ES, m/z) calculated for C32H37N4O4Cl2[(M+H)+]611.2187, observed 611.2195.

Workup

  1. filtrationThe light yellow solution was filtered

Sources & evidence

ORD record
ord-6206b6c5d0ec4959ac2b98dcafe61398
Source dataset
uspto-grants-2004_05
Patent number
US06734302B2

Reaction notes

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