Hydrochloric Acid → Ethyl 2-cyclopentyloxy-4-methoxy-benzimidate hydrochloride

Participants

Reaction Steps

Hydrogen chloride gas was passed through a solution of 2-cyclopentyloxy-4-methoxy-benzonitrile (0.12 g, 0.55 mmol) in absolute ethanol (15 mL) in a pressure tube for 1 h at 0° C. The tube was sealed and stirred at room temperature for 3 d. Evaporation of the solvents and trituration of the residue in diethyl ether gave ethyl 2-cyclopentyloxy-4-methoxy-benzimidate hydrochloride (0.17 g, 100%).

Provenance & Evidence