Hydrochloric Acid → Ethyl 2-cyclopentyloxy-4-methoxy-benzimidate hydrochloride

HRID 1582481Notes

Reaction equation

HRID 1582481 reaction equation
[ClH:1].[CH:2]1([O:7][C:8]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH2:18]([OH:20])[CH3:19]>>[ClH:1].[CH:2]1([O:7][C:8]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:9]=2[C:10](=[NH:11])[O:20][CH2:18][CH3:19])[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 227211652-Cyclopentyloxy-4-methoxy-benzonitrile

Product 1

HCID 22721083Ethyl 2-cyclopentyloxy-4-methoxy-benzimidate hydrochlorideYield 100%

Procedure

Hydrogen chloride gas was passed through a solution of 2-cyclopentyloxy-4-methoxy-benzonitrile (0.12 g, 0.55 mmol) in absolute ethanol (15 mL) in a pressure tube for 1 h at 0° C. The tube was sealed and stirred at room temperature for 3 d. Evaporation of the solvents and trituration of the residue in diethyl ether gave ethyl 2-cyclopentyloxy-4-methoxy-benzimidate hydrochloride (0.17 g, 100%).

Workup

  1. customThe tube was sealed
  2. customEvaporation of the solvents and trituration of the residue in diethyl ether

Sources & evidence

ORD record
ord-85bdb4987e5548aba0a2c3859ccdabd0
Source dataset
uspto-grants-2004_05
Patent number
US06734302B2

Reaction notes

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