Hydrochloric Acid → HCID 22721156, compound

HRID 1582487Notes

Reaction equation

HRID 1582487 reaction equation
[ClH:1].[CH2:2]([O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([O:13][CH:14]([CH3:16])[CH3:15])[CH:6]=1)[CH3:3].[CH2:17]([OH:19])[CH3:18]>>[ClH:1].[CH2:2]([O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9](=[NH:10])[O:19][CH2:17][CH3:18])=[C:7]([O:13][CH:14]([CH3:15])[CH3:16])[CH:6]=1)[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22721205HCID 22721205, compound

Product 1

HCID 22721156HCID 22721156, compound

Procedure

Hydrogen chloride gas was passed through a solution of 4-ethoxy-2-isopropoxy-benzonitrile (0.30 g, 1.46 mmol) in absolute ethanol (100 mL) in a pressure tube for 45 min at 0° C. The tube was sealed and stirred at room temperature for 4 d. The pressure was released only after the tube is cooled to 0° C. Evaporation of the solvents and trituration of the residue in diethyl ether gave ethyl 4-ethoxy-2-isopropoxy-benzimidate hydrochloride which was used without further purification.

Workup

  1. customThe tube was sealed
  2. temperatureis cooled to 0° C
  3. customEvaporation of the solvents and trituration of the residue in diethyl ether

Sources & evidence

ORD record
ord-138dfde3acd048f89844606d3d40f9b4
Source dataset
uspto-grants-2004_05
Patent number
US06734302B2

Reaction notes

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