Propylene Oxide → HCID 22721141, compound

HRID 1582491Notes

Reaction equation

HRID 1582491 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[O:21])[C:10]([C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=3[O:36][CH:37]([CH3:39])[CH3:38])=[N:9]2)=[CH:4][CH:3]=1.[CH2:40]1[O:43][CH:41]1[CH3:42]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:23][CH2:24][N:25]([CH2:40][CH:41]([OH:43])[CH3:42])[CH2:26][CH2:27]3)=[O:21])[C:10]([C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=3[O:36][CH:37]([CH3:39])[CH3:38])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6378Propylene OxideHCID 22721056HCID 22721056, compound

Product 1

HCID 22721141HCID 22721141, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound was prepared by the treatment of [4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-piperazin-1-yl-methanone (example 10 g) with propylene oxide in methanol for 7 h at 45° C. in a sealed tube. HR-MS (ES, m/z) calculated for C33H38N4O4Cl2[(M+H)+]625.2343, observed 625.2350.

Sources & evidence

ORD record
ord-1cac39a901874c008f91fa74f7e7b9d9
Source dataset
uspto-grants-2004_05
Patent number
US06734302B2

Reaction notes

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