Chloroacetone → HCID 22721154, compound

HRID 1582492Notes

Reaction equation

HRID 1582492 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[O:21])[C:10]([C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=3[O:36][CH:37]([CH3:39])[CH3:38])=[N:9]2)=[CH:4][CH:3]=1.Cl[CH2:41][C:42](=[O:44])[CH3:43]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:22]3[CH2:23][CH2:24][N:25]([CH2:41][C:42](=[O:44])[CH3:43])[CH2:26][CH2:27]3)=[O:21])[C:10]([C:28]3[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=3[O:36][CH:37]([CH3:39])[CH3:38])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 22721056HCID 22721056, compound

Product 1

HCID 22721154HCID 22721154, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The compound was prepared by the treatment of [4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]piperazin-1-yl-methanone (example 10 g) with chloroacetone and triethylamine at 40° C. overnight. HR-MS (ES, m/z) calculated for C33H36N4O4Cl2[(M+H)+]623.2187, observed 623.2194.

Sources & evidence

ORD record
ord-6fffed4c06504f27b23eb511cb76b090
Source dataset
uspto-grants-2004_05
Patent number
US06734302B2

Reaction notes

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